Fundamentals of Mass Spectrometry used in Toxicology
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This module will review combining chromatography and mass spectrometry for the confirmatory test to identify and quantify the specific compound, drug, or drug metabolite. The purpose of mass spectrometry is to obtain a unique, reproducible fragmentation pattern of a particular molecular species. Whether a mass spectrometer uses a direct introduction source, gas chromatography (or GC), or liquid chromatography (or LC), some components are common for all instruments.
Specifically, an ionization source is at the inlet, followed by a mass selective detector that allows for the selection of particular masses, and the final component is a detector that translates and amplifies the selected ion signal into an electronic signal sufficient for data processing. This course will cover these three components for the major types of nominal mass and higher-resolution mass spectrometer instrumentation currently available.
Course Type: On-Demand Presentation
Length: Approximately 70 minutes
Performance Requirement: Interactive questions will be included in the material to ensure participants understand the material. Documentation will be provided for attendance.
Course Accreditation: Certificate of Attendance